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Huntington’s Disease and Antisense Drugs

Many of you may have heard the exciting news on December 11, 2017 about a potential treatment for Huntington’s disease! If not; an Ionis Pharmaceuticals drug, HTTRx, has been shown to be well tolerated and exhibit dose dependent reduction of mHTT in a Phase 1/2a study that is ongoing at University College in London! This has lead Roche …

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Bioluminescence is Weird. And Useful.

You’ve already seen bioluminescence…even if you don’t realize it. Like the words fireplace, meatball, flatbread and blackbird, Green Fluorescent Protein has a name that lets you know what it does without having to know too much else about it. I imagine that the people who named mouthwash and bedroom were probably just very lazy, or …

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The Practical Spectrometer

Since 2007 BMG LABTECH has used UV/vis spectrometers in their microplate readers for absorbance measurements. In fact, BMG LABTECH was the first company to incorporate a UV/vis absorbance spectrometer into a multifunction microplate reader. But, what is an absorbance spectrometer and what makes it unique? A vital clue to the functionality of a spectrometer exists …

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What is a dichroic mirror?

If you’ve used a microscope or a filter based plate reader you’ve probably heard the term “dichroic” at some point. And if you’ve read the term “dichroic mirror” maybe you’ve always wondered what kinds of other words might follow that term in a sentence but have never made it that far. If you’ve made it this far, …

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CLARIOstar – measuring sub-picogram levels of dsDNA

The CLARIOstar is the most sensitive Microplate Reader tested for dsDNA Concentration, as shown with Biotium’s new AccuBlueTM NextGen dsDNA Dye. As Genomic DNA sequencing techniques develop, like single cell sequencing, greater sensitivity using lower amounts of DNA is desired. Sensitivity using UV/Vis Absorbance techniques (i.e. 260 nm) is limited by Beer’s law, therefore fluorescence …

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